導師介紹 | ||
導師姓名 | 許旭 |
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導師性別 | 男 | |
職務職稱 | 教授 | |
所在院系 | 化學與環境工程學院 | |
一級學科 | 化學工程與技術 | |
二級學科 | 制藥工程 | |
研究方向 | 藥物分析與質量控制 | |
聯系電話 | 60873372, 18017581856 | |
電子郵箱 | ||
個人簡介 | ||
分析化學教研室教授，化工學院分析測試中心主任。1991年開始至今一直從事色譜與儀器分析及其應用方面的研究工作，包括手性藥物拆分、中藥復方與有效成分研究、食品分析、生物大分子分離分析、體液藥物分析、以及分析儀器等方面的研究。主持承擔國家自然科學基金、上海市自然科學基金、企業委托課題等。在Journal of Chromatography A、International Journal of Mass Spectrometry、Frontiers in Plant Science、Journal of the American Oil Chemists Society、Chirality等雜志發表學術論文163篇（其中SCI論文82篇），授權專利17項。 | ||
學習與工作經歷 | ||
1996年在中國藥科大學獲博士學位。中科院大連化學物理研究所博士后。之后在上海市藥品檢驗所任副研究員、副主任（其中1998.11-1999.7到瑞典Uppsala University訪問學者）。2000.6到中科院上海有機化學研究所，先后任副研究員、色譜組組長、研究員。2009.7到上海應用技術學院化學與環境工程學院工作。 | ||
科研工作與成果 | ||
近期發表的代表性SCI論文： 1. Dan-Yang Shi, Yu Zheng, Qiang-Sheng Guo, Can Gong, Xu Xu*, Jian-Ping Gao*, Determination of Total Phenol and Six Polyphenolic Components in Cinnamomi Cortex Polyphenol Extract by Quantitative Nuclear Magnetic Resonance Spectroscopy, Analytical Methods, 2023, 15, 6561–6570 2. Yu-Lin Shen, Si-Jia Zhuang, Fan Yang, Can Gong, Xu Xu*. Prefabricated platinum nanomaterial matrix for MALDI-MS imaging of oligosaccharides and lipids in plant tissues. Frontiers in Plant Science. 2023, 14:1105374. 3. Hongyu Sun, Siyu He（共一作者）, Li Wu, Zeying Cao, Xian Sun, Mingwei Xu, Shan Lu, Mingdi Xu, Baoming Ning, Huimin Sun, Tiqiao Xiao, Peter York,Xu Xu*, Xianzhen Yin*, Jiwen Zhang*. Bridging the structure gap between pellets in artificial dissolution media and in gastrointestinal tract in rats. Acta Pharmaceutica Sinica B, 12(1): 326-338, 2022. 4. Yang Xu, Yingzhi Deng, Rongrong Ye, Can Gong, Zhaoxin Liu, Yuezhen Zhao, Yan Lu*, Jinggen Liu, Xu Xu*, MALDI-MS imaging of lipids and small molecules in rat brain tissue based on graphene oxide film pre-coated matrix, International Journal of Mass Spectrometry, 464: 116573, 2021 5. Jia- Hua Feng, Ke- Zhao Wei, Jian- Ping Gao*, Xu Xu*, Determination of adenosine phosphates in mouse myocardium tissue by HPLC with UV detection and using porous graphite carbon column, Journal of Chromatography B, 1145: 122110, 2020 6. 肖坤，龔燦，郭強勝，許旭*，定量核磁共振碳譜同時測定食用油中甘油三酯的sn-1,3和sn-2脂肪酸含量，分析化學，48(6): 802-810, 2020 7. Jia-Lin Du, Xing-Li Pei, Hai-Yan Zhao, Can Gong*, Xu Xu*, Identification of fatty acids and triacylglycerols in Schisandrae chinensis fructus oil, Journal of Analytical Chemistry, 2020, 75(8): 1024–1032. 8. 陸湘婷，張世鼎，龔燦，許旭*，基于多孔石墨碳柱和正辛烷-異丙醇流動相的高效液相色譜法分離分析食用油中的甘油三酯，分析化學，48(8):1084-1095，2020 9. Xing-Li Pei, Xiao-Ning Liu, Jia-Lin Du, Can Gong, Xu Xu*, MALDI-MS imaging of lipids in corn using a flexible ultrasonic spraying device as matrix deposition method, International Journal of Mass Spectrometry, 455: 116373, 2020 10. 趙玥禎，徐楊，龔燦，鞠鈺蕊，劉兆鑫，許旭*，納米四氧化三鐵基質用于基質輔助激光解吸電離質譜法分析小分子化合物, 分析化學，49(1): 103-112，2021 11. Yang Xu, Yingzhi Deng, Rongrong Ye, Can Gong, Zhaoxin Liu, Yuezhen Zhao, Yan Lu*, Jinggen Liu, Xu Xu*, MALDI-MS imaging of lipids and small molecules in rat brain tissue based on graphene oxide film pre-coated matrix, International Journal of Mass Spectrometry, 464: 116573, 2021 12. Jia-Lin Du, Can Gong?, Xing-Li Pei, Hai-Yan Zhao, Xu Xu*, Analysis of triacylglycerols in castor oil by LC-MS and FTICR-MS based on GC-MS,Journal of Chromatographic Science, 57(2):108–115, 2019 13. 劉曉寧，裴興麗，龔燦，許旭*，基于離子液體的基質輔助激光解吸電離質譜成像分析桑葉表面和葉脈切片中的小分子成分，分析化學，46(12): 1923~1930, 2018 14. Shi-Ding Zhang, Can Gong, Yan Lu*, Xu Xu*, Separation of triacylglycerols in edible oil by LC-MS with porous graphitic carbon column and toluene-based mobile phase, Journal of the American Oil Chemists Society, 95(10):1253-1266, 2018 15. Xinda Liu, Xiaodong Tian, Xu Xu*, Choiwan Lau, Jianzhong Lu*, Design of a Phosphinate-based Bioluminescent Probe for Superoxide Radical Anion Imaging in Living Cells, Luminescence, 33(6):1101-1106, 2018 16. Yao-Li Zhang, Can Gong, Xing-Li Pei, Yu-Liang Han, Yu-Yu Huang, Xu Xu*, Rapid quantitative determination of triglycerides in edible oils by matrix-assisted laser desorption/ionisation Fourier transform ion cyclotron resonance mass spectrometry using pencil graphite combined with 2,5-dihydroxybenzoic acid as matrix, International Journal of Mass Spectrometry, 431:56-62, 2018 17. Longwei Fang, Xianzhen Yin（共一作者）, Li Wu, Yaping He, Yuanzhi He, Wei Qin, Fanyue Meng, Peter York, Xu Xu*, Jiwen Zhang*, Classification of microcrystalline celluloses via structures of individual particles measured by synchrotron radiation X-ray micro-computed tomography, International Journal of Pharmaceutics, 531(2): 658-667, 2017 18. 黃煜宇，肖坤，裴興麗，韓玉良，龔燦，許旭*，使用尖玻片、毛細管和尖滴管三種玻璃尖端電噴霧離子化質譜分析方法. 分析化學, 46(4): 578-585, 2018 19. Xiao-Lin Shan, Xiao-Ting Liu, Can Gong, Xu Xu*, Precolumn Derivatization with Bromine to Improve Separation and Detection Sensitivity of Triacylglycerols in Edible Oil by Reversed-Phase High Performance Liquid Chromatography,Analytical Sciences, 34(3):283-289,2018 20. 趙海燕，龔燦，許旭*，反相液相色譜-質譜法使用甲酸甲胺改善甘油三酯電噴霧離子化檢測靈敏度. 分析化學, 45(9): 1323-1329, 2017 21. 裴興麗，黃煜宇，龔燦，許旭*，基于離子液體基質的大豆中寡糖成分MALDI- MS成像分析，分析化學，45(8) :1155 ~1164, 2017 22. 劉曉婷，禹珊，袁銘，郭強勝，龔燦，許旭*，固相萃取-定量核磁共振波譜法測定板藍根飲片中的表告依春，分析化學，45(7) :1059 ~1065, 2017 23. 張耀利，裴興麗，龔燦，韓玉良，倪天強，王帆，王盛君，盧海鵬，許旭*，大氣壓化學電離-高分辨質譜譜直接分析食用油中的甘油三酯，分析化學，45(2): 183-190, 2017 24. Botao Liu, Haiyan Li, Xiaonan Xu, Xue Li, Nana Lv, Vikramjeet Singh, J. Fraser Stoddart, Peter York, Xu Xu*, Ruxandra Gref*, Jiwen Zhang*, Optimized syntheses and crystalline stability of γ-Cyclodextrin metal-organic frameworks for drug adsorption,International Journal of Pharmaceutics, 514(1), 212–219, 2016 25. Xue Fu, Jianhui Li, Lianyan Wang, Bing Wu, Xu Xu*, Zongwu Deng, Hailu Zhang*, Pharmaceutical Crystalline Complexes of Sulfamethazine with Saccharin: Same Interaction Site but Different Ionization State, RSC Adv., 6(31): 26474-26478, 2016 26. Xiao-Rui Lei, Can Gong, Yao-Li Zhang, Xu Xu*, Influence of the acetamide from acetonitrile hydrolysis in acid-contained mobile phase on the ultraviolet detection in high performance liquid chromatography, Chromatographia, 79:1257-1262, 2016 27. 何榕，山曉琳，董方圓，許旭*，反相超效液相色譜-質譜聯用分離分析食用油中的甘油三酯，分析化學，43(9):1377-1382, 2015 28. Xiaolong Lu, Zuhua Liao, Xue Li, Manli Wang, Li Wu, Haiyan Li, Peter York, Xu Xu*, Xianzhen Yin*, Jiwen Zhang*, Powder Technology, 281: 49-56, 2015 29. 韓玉良，張耀利，楊宇輝，黃煜宇，許旭*，簡便型實時直接分析質譜進樣裝置，分析化學，43(3): 451-456, 2015 30. 禹珊，郭強勝，王會琳，高建平，許旭*，定量核磁共振波譜法同時測定中藥虎杖中白藜蘆醇和虎杖苷的含量，分析化學，43(1): 69~74, 2015 （該文2016和2017年兩次被評為上年度中國精品科技期刊“F5000”論文）
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社會學術團體兼職 | ||
五種學術期刊《色譜》、《分析試驗室》、《理化檢驗-化學分冊》、《Journal of Chinese Pharmaceutical Sciences》、《應用技術學報》的編委。 | ||
主要研究方向 | ||
質譜、色譜、NMR等儀器分析方法及其應用研究。包括藥物分析（中藥分析、體液分析等）、食品分析（食用油分析）等。 | ||
近3年指導研究生的就業情況 | ||
近3年累計畢業11名研究生。其中1名讀博，1名到政府單位，其他均在江浙滬的新藥研發、分析檢測相關公司。 | ||
